Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway

Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway

Growth differentiation factor-15 (GDF-15) and its receptor GFRAL are both involved in the development of obesity and insulin resistance. Plasmatic GDF-15 level increases with obesity and is positively associated with disease progression. Despite macrophages have been recently suggested as a key sour...

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Bibliographic Details
Main Authors: Laurent L’homme, Benan Pelin Sermikli, Bart Staels, Jacques Piette, Sylvie Legrand-Poels, David Dombrowicz
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Nutrients
Subjects:
GDF15
macrophage
obesity
saturated fatty acids
stearate
ER stress
Online Access:https://www.mdpi.com/2072-6643/12/12/3771

Internet

https://www.mdpi.com/2072-6643/12/12/3771

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