Staphylococcal Entertotoxins of the Enterotoxin Gene Cluster (egcSEs) Induce Nitrous Oxide- and Cytokine Dependent Tumor Cell Apoptosis in a Broad Panel of Human Tumor Cells

Staphylococcal Entertotoxins of the Enterotoxin Gene Cluster (egcSEs) Induce Nitrous Oxide- and Cytokine Dependent Tumor Cell Apoptosis in a Broad Panel of Human Tumor Cells

The egcSEs comprise five genetically linked staphylococcal enterotoxins, SEG, SEI, SElM, SElN and SElO and two pseudotoxins which constitute an operon present in up to 80% of Staphylococcus aureus isolates. A preparation containing theses proteins was recently used to treat advanced lung cancer with...

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Bibliographic Details
Main Authors: David eTerman, Asma eSerier, Olivier eDauwalder, Cedric eBadiou, A eDutour, Damien eThomas, Virginie eBrun, Jacques eBienvenu, Jérôme eEtienne, François eVandenesch, Gerard eLina
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Apoptosis
Nitrous Oxide
Staphylococcus aureus
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha
egcSE superantigens
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00038/full

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http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00038/full

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