Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity

Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity

The molecular mechanisms underlying cardiac chamber formation are not well understood. Here, the authors show that planar cell polarity signalling through Wnt5b and Wnt11 coordinates localised and tissue-scale polarised actomyosin contractility in the zebrafish heart, regulating cardiac chamber form...

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Bibliographic Details
Main Authors: Anne Margarete Merks, Marie Swinarski, Alexander Matthias Meyer, Nicola Victoria Müller, Ismail Özcan, Stefan Donat, Alexa Burger, Stephen Gilbert, Christian Mosimann, Salim Abdelilah-Seyfried, Daniela Panáková
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04566-1

Internet

https://doi.org/10.1038/s41467-018-04566-1

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