Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity

The molecular mechanisms underlying cardiac chamber formation are not well understood. Here, the authors show that planar cell polarity signalling through Wnt5b and Wnt11 coordinates localised and tissue-scale polarised actomyosin contractility in the zebrafish heart, regulating cardiac chamber form...

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Main Authors:	Anne Margarete Merks, Marie Swinarski, Alexander Matthias Meyer, Nicola Victoria Müller, Ismail Özcan, Stefan Donat, Alexa Burger, Stephen Gilbert, Christian Mosimann, Salim Abdelilah-Seyfried, Daniela Panáková
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04566-1

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spelling	doaj-3e6df84b48be483bbf76b4b5ec7606cd2021-05-11T09:36:59ZengNature Publishing GroupNature Communications2041-17232018-06-019111510.1038/s41467-018-04566-1Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activityAnne Margarete Merks0Marie Swinarski1Alexander Matthias Meyer2Nicola Victoria Müller3Ismail Özcan4Stefan Donat5Alexa Burger6Stephen Gilbert7Christian Mosimann8Salim Abdelilah-Seyfried9Daniela Panáková10Electrochemical Signaling in Development and Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz AssociationElectrochemical Signaling in Development and Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz AssociationElectrochemical Signaling in Development and Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz AssociationElectrochemical Signaling in Development and Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz AssociationElectrochemical Signaling in Development and Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz AssociationInstitute for Biochemistry and Biology, Animal Physiology, University PotsdamInstitute of Molecular Life Sciences, University of ZürichMathematical Cell Physiology, Max Delbrück Centre for Molecular Medicine in the Helmholtz AssociationInstitute of Molecular Life Sciences, University of ZürichInstitute for Biochemistry and Biology, Animal Physiology, University PotsdamElectrochemical Signaling in Development and Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz AssociationThe molecular mechanisms underlying cardiac chamber formation are not well understood. Here, the authors show that planar cell polarity signalling through Wnt5b and Wnt11 coordinates localised and tissue-scale polarised actomyosin contractility in the zebrafish heart, regulating cardiac chamber formation and looping.https://doi.org/10.1038/s41467-018-04566-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Anne Margarete Merks Marie Swinarski Alexander Matthias Meyer Nicola Victoria Müller Ismail Özcan Stefan Donat Alexa Burger Stephen Gilbert Christian Mosimann Salim Abdelilah-Seyfried Daniela Panáková
spellingShingle	Anne Margarete Merks Marie Swinarski Alexander Matthias Meyer Nicola Victoria Müller Ismail Özcan Stefan Donat Alexa Burger Stephen Gilbert Christian Mosimann Salim Abdelilah-Seyfried Daniela Panáková Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity Nature Communications
author_facet	Anne Margarete Merks Marie Swinarski Alexander Matthias Meyer Nicola Victoria Müller Ismail Özcan Stefan Donat Alexa Burger Stephen Gilbert Christian Mosimann Salim Abdelilah-Seyfried Daniela Panáková
author_sort	Anne Margarete Merks
title	Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
title_short	Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
title_full	Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
title_fullStr	Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
title_full_unstemmed	Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
title_sort	planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-06-01
description	The molecular mechanisms underlying cardiac chamber formation are not well understood. Here, the authors show that planar cell polarity signalling through Wnt5b and Wnt11 coordinates localised and tissue-scale polarised actomyosin contractility in the zebrafish heart, regulating cardiac chamber formation and looping.
url	https://doi.org/10.1038/s41467-018-04566-1
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Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity

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