Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons

Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons

Two mammalian genes, Kcnt1 and Kcnt2, encode pore-forming subunits of Na+-dependent K+ (KNa) channels. Progress in understanding KNa channels has been hampered by the absence of specific tools and methods for rigorous KNa identification in native cells. Here, we report the genetic disruption of both...

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Bibliographic Details
Main Authors: Pedro L Martinez-Espinosa, Jianping Wu, Chengtao Yang, Vivian Gonzalez-Perez, Huifang Zhou, Hongwu Liang, Xiao-Ming Xia, Christopher J Lingle
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-11-01
Series:eLife
Subjects:
itch
SLO2
KNa current
DRG
pain
Online Access:https://elifesciences.org/articles/10013

Internet

https://elifesciences.org/articles/10013

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