Sequential Blockade of PD-1 and PD-L1 Causes Fulminant Cardiotoxicity—From Case Report to Mouse Model Validation

Sequential Blockade of PD-1 and PD-L1 Causes Fulminant Cardiotoxicity—From Case Report to Mouse Model Validation

The combined administration of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors might be considered as a treatment for poorly responsive cancer. We report a patient with brain metastatic lung adenocarcinoma in whom fatal myocarditis developed after sequential use...

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Bibliographic Details
Main Authors: Shin-Yi Liu, Wen-Chien Huang, Hung-I Yeh, Chun-Chuan Ko, Hui-Ru Shieh, Chung-Lieh Hung, Tung-Ying Chen, Yu-Jen Chen
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
check point inhibitors
programmed cell death protein 1
programmed cell death 1 ligand 1
cardiotoxicity
lung metastasis
Online Access:https://www.mdpi.com/2072-6694/11/4/580

Internet

https://www.mdpi.com/2072-6694/11/4/580

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