Efficacy and Tolerability of First Line Arsenic Trioxide in Combination With All-Trans Retinoic Acid in Patients With Acute Promyelocytic Leukemia: Real Life Experience

Efficacy and Tolerability of First Line Arsenic Trioxide in Combination With All-Trans Retinoic Acid in Patients With Acute Promyelocytic Leukemia: Real Life Experience

Acute promyelocytic leukemia is a variant of acute myeloid leukemia characterized by t(15;17) and PML/RAR alfa fusion gene. The discovery of the molecular pathogenesis has led to entitle all-trans retinoic acid (ATRA) as the first targeted therapy for acute leukemia. It is usually associated to anth...

Full description

Bibliographic Details
Main Authors: Francesco Autore, Patrizia Chiusolo, Federica Sorà, Sabrina Giammarco, Luca Laurenti, Idanna Innocenti, Elisabetta Metafuni, Nicola Piccirillo, Livio Pagano, Simona Sica
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
acute promyelocytic leukemia
arsenic trioxide
all-trans retinoic acid
first-line
secondary leukemias
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.614721/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.614721/full

Similar Items