The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan.

Ethosuximide is a medication used to treat seizure disorders in humans, and we previously demonstrated that ethosuximide can delay age-related changes and extend the lifespan of the nematode Caenorhabditis elegans. The mechanism of action of ethosuximide in lifespan extension is unknown, and elucida...

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Bibliographic Details
Main Authors: James J Collins, Kimberley Evason, Christopher L Pickett, Daniel L Schneider, Kerry Kornfeld
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2565500?pdf=render