The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo.

The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo.

Microvascular inflammation occurs during sepsis and the endogenous opioid-like peptide nociceptin/orphanin FQ (N/OFQ) is known to regulate inflammation. This study aimed to determine the inflammatory role of N/OFQ and its receptor NOP (ORL1) within the microcirculation, along with anti-inflammatory...

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Bibliographic Details
Main Authors: Zoë L S Brookes, Emily N Stedman, Nicola J Brown, Christopher P Hebbes, Remo Guerrini, Girolamo Calo, Charles S Reilly, David G Lambert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3781147?pdf=render

Internet

http://europepmc.org/articles/PMC3781147?pdf=render

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