Simulation, In Vitro, and In Vivo Cytotoxicity Assessments of Methotrexate-Loaded pH-Responsive Nanocarriers

Simulation, In Vitro, and In Vivo Cytotoxicity Assessments of Methotrexate-Loaded pH-Responsive Nanocarriers

In this study, pH-responsive niosomal methotrexate (MTX) modified with ergosterol was prepared for potential anticancer application. The prepared formulation had a size of 176.7 ± 3.4 nm, zeta potential of −31.5 ± 2.6 mV, EE% of 76.9 ± 2.5%, and a pH-responsive behavior in two different pHs (5.4 and...

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Bibliographic Details
Main Authors: Mahmood Barani, Mohammad Reza Hajinezhad, Saman Sargazi, Mahira Zeeshan, Abbas Rahdar, Sadanand Pandey, Mehrdad Khatami, Farshid Zargari
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Polymers
Subjects:
methotrexate
niosome
pH-responsive
in-vitro
in-vivo
simulation
Online Access:https://www.mdpi.com/2073-4360/13/18/3153

Internet

https://www.mdpi.com/2073-4360/13/18/3153

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