Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization

Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization

PPARγ has emerged as a master regulator of macrophage polarization and is the molecular target of the thiazolidinedione drugs. Here we show that apigenin binds and activates PPARγ by acting as a modulator. Activation of PPARγ by apigenin blocks p65 translocation into nuclei through inhibition of p65...

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Bibliographic Details
Main Authors: Xiujing Feng, Dan Weng, Feifei Zhou, Young D. Owen, Haohan Qin, Jingfa Zhao, WenYu, Yahong Huang, Jiajia Chen, Haijian Fu, Nanfei Yang, Dianhua Chen, Jianxin Li, Renxiang Tan, Pingping Shen
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:EBioMedicine
Subjects:
Obesity-related inflammation
Macrophage polarization
Apigenin
PPARγ
NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416302754

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http://www.sciencedirect.com/science/article/pii/S2352396416302754

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