Molecular Signatures of a TLR4 Agonist-Adjuvanted HIV-1 Vaccine Candidate in Humans

Molecular Signatures of a TLR4 Agonist-Adjuvanted HIV-1 Vaccine Candidate in Humans

Systems biology approaches have recently provided new insights into the mechanisms of action of human vaccines and adjuvants. Here, we investigated early transcriptional signatures induced in whole blood of healthy subjects following vaccination with a recombinant HIV-1 envelope glycoprotein subunit...

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Bibliographic Details
Main Authors: Jenna Anderson, Thorunn A. Olafsdottir, Sven Kratochvil, Paul F. McKay, Malin Östensson, Josefine Persson, Robin J. Shattock, Ali M. Harandi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
HIV vaccine
systems vaccinology
transcriptomics
adjuvant
glucopyranosyl lipid adjuvant-aqueous formulation
TLR4
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00301/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00301/full

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