Investigation of brain tissue infiltration by medulloblastoma cells in an ex vivo model

Abstract Medulloblastoma (MB) is a paediatric cancer of the cerebellum that can develop cerebellar and leptomeningeal metastases. Local brain tissue infiltration, the underlying cause of metastasis and relapse, remains unexplored. We developed a novel approach to investigate tissue infiltration of M...

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Bibliographic Details
Main Authors: Anuja Neve, Karthiga Santhana Kumar, Dimitra Tripolitsioti, Michael A. Grotzer, Martin Baumgartner
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05573-w