Turning the tables on cytomegalovirus: targeting viral Fc receptors by CARs containing mutated CH2–CH3 IgG spacer domains

Turning the tables on cytomegalovirus: targeting viral Fc receptors by CARs containing mutated CH2–CH3 IgG spacer domains

Abstract Background During infection with human cytomegalovirus (HCMV) several viral proteins occur on cell surfaces in high quantity. We thus pursue an HLA-independent approach for immunotherapy of HCMV using chimeric antigen receptors (CARs) and bispecific BiTE® antibody constructs. In this contex...

Full description

Bibliographic Details
Main Authors: Julia Proff, Charlotte U. Brey, Armin Ensser, Wolfgang Holter, Manfred Lehner
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Translational Medicine
Subjects:
Cytomegalovirus
Chimeric antigen receptor (CAR)
Glycoprotein B (gB)
Fc receptors
CH2–CH3 domain
IgG
Online Access:http://link.springer.com/article/10.1186/s12967-018-1394-x

Internet

http://link.springer.com/article/10.1186/s12967-018-1394-x

Similar Items