WISP3 (CCN6) Is a Secreted Tumor-Suppressor Protein that Modulates IGF Signaling in Inflammatory Breast Cancer

WISP3 (CCN6) Is a Secreted Tumor-Suppressor Protein that Modulates IGF Signaling in Inflammatory Breast Cancer

Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer. We have found that WISP3 is lost in 80% of human IBC tumors and that it has growth- and angiogenesis-inhibitory functions in breast cancer in vitro and in vivo. WISP3 is a cysteine-rich, putatively secreted...

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Bibliographic Details
Main Authors: Celina G. Kleer, Yanhong Zhang, Quintin Pant, Sofia D. Merajver
Format: Article
Language:English
Published: Elsevier 2004-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
IGF-binding proteins
MAPK signaling
cell proliferation
cell cycle control
ERK-1/2 phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558604800642

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http://www.sciencedirect.com/science/article/pii/S1476558604800642

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