Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug therapy

Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug therapy

Background: Kidney transplant recipients (KTRs) with “operational tolerance” (OT) maintain a functioning graft without immunosuppressive (IS) drugs, thus avoiding treatment complications. Nevertheless, IS drugs can influence gene-expression signatures aiming to identify OT among treated KTRs. Method...

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Bibliographic Details
Main Authors: Sofia Christakoudi, Manohursingh Runglall, Paula Mobillo, Irene Rebollo-Mesa, Tjir-Li Tsui, Estefania Nova-Lamperti, Catharine Taube, Sonia Norris, Yogesh Kamra, Rachel Hilton, Titus Augustine, Sunil Bhandari, Richard Baker, David Berglund, Sue Carr, David Game, Sian Griffin, Philip A. Kalra, Robert Lewis, Patrick B. Mark, Stephen D. Marks, Iain MacPhee, William McKane, Markus G. Mohaupt, Estela Paz-Artal, Sui Phin Kon, Daniel Serón, Manish D. Sinha, Beatriz Tucker, Ondrej Viklický, Daniel Stahl, Robert I. Lechler, Graham M. Lord, Maria P. Hernandez-Fuentes
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:EBioMedicine
Subjects:
Kidney
Transplantation
Operational Tolerance
Biomarkers
Immunosuppressive Drugs
RT-qPCR
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420302747

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http://www.sciencedirect.com/science/article/pii/S2352396420302747

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