Cytomegalovirus Restructures Lipid Rafts via a US28/CDC42-Mediated Pathway, Enhancing Cholesterol Efflux from Host Cells

Cytomegalovirus Restructures Lipid Rafts via a US28/CDC42-Mediated Pathway, Enhancing Cholesterol Efflux from Host Cells

Cytomegalovirus (HCMV) contains cholesterol, but how HCMV interacts with host cholesterol metabolism is unknown. We found that, in human fibroblasts, HCMV infection increased the efflux of cellular cholesterol, despite reducing the abundance of ABCA1. Mechanistically, viral protein US28 was acting t...

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Bibliographic Details
Main Authors: Hann Low, Nigora Mukhamedova, Huanhuan L. Cui, Brian P. McSharry, Selmir Avdic, Anh Hoang, Michael Ditiatkovski, Yingying Liu, Ying Fu, Peter J. Meikle, Martin Blomberg, Konstantinos A. Polyzos, William E. Miller, Piotr Religa, Michael Bukrinsky, Cecilia Soderberg-Naucler, Barry Slobedman, Dmitri Sviridov
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716306830

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http://www.sciencedirect.com/science/article/pii/S2211124716306830

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