Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing

Diabetic foot ulcers (DFU) represent a complex disease with limited treatment options. Here, the authors compare human RNASeq patient data from DFU, oral mucosa and skin acute wounds, identifying FOXM1 as a mediator of macrophage and neutrophil recruitment, which contributes to disease pathogenesis...

Full description

Bibliographic Details
Main Authors: Andrew P. Sawaya, Rivka C. Stone, Stephen R. Brooks, Irena Pastar, Ivan Jozic, Kowser Hasneen, Katelyn O’Neill, Spencer Mehdizadeh, Cheyanne R. Head, Natasa Strbo, Maria I. Morasso, Marjana Tomic-Canic
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18276-0