Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing
Diabetic foot ulcers (DFU) represent a complex disease with limited treatment options. Here, the authors compare human RNASeq patient data from DFU, oral mucosa and skin acute wounds, identifying FOXM1 as a mediator of macrophage and neutrophil recruitment, which contributes to disease pathogenesis...
Main Authors: | Andrew P. Sawaya, Rivka C. Stone, Stephen R. Brooks, Irena Pastar, Ivan Jozic, Kowser Hasneen, Katelyn O’Neill, Spencer Mehdizadeh, Cheyanne R. Head, Natasa Strbo, Maria I. Morasso, Marjana Tomic-Canic |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-09-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-18276-0 |
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