De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function.

De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function.

The splicing regulator Polypyrimidine Tract Binding Protein (PTBP1) has four RNA binding domains that each binds a short pyrimidine element, allowing recognition of diverse pyrimidine-rich sequences. This variation makes it difficult to evaluate PTBP1 binding to particular sites based on sequence al...

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Bibliographic Details
Main Authors: Areum Han, Peter Stoilov, Anthony J Linares, Yu Zhou, Xiang-Dong Fu, Douglas L Black
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3907290?pdf=render

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http://europepmc.org/articles/PMC3907290?pdf=render

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