Cross Talk between NOTCH Signaling and Biomechanics in Human Aortic Valve Disease Pathogenesis

Cross Talk between NOTCH Signaling and Biomechanics in Human Aortic Valve Disease Pathogenesis

Aortic valve disease is a burgeoning public health problem associated with significant mortality. Loss of function mutations in NOTCH1 cause bicuspid aortic valve (BAV) and calcific aortic valve disease. Because calcific nodules manifest on the fibrosa side of the cusp in low fluidic oscillatory she...

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Bibliographic Details
Main Authors: Richard C. Godby, Charu Munjal, Amy M. Opoka, J. Michael Smith, Katherine E. Yutzey, Daria A. Narmoneva, Robert B. Hinton
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
mechanobiology
NOTCH
aortic valve
biomedical engineering
mechanotransduction
Online Access:http://www.mdpi.com/2308-3425/1/3/237

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http://www.mdpi.com/2308-3425/1/3/237

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