A Genetic Screen Reveals an Unexpected Role for Yorkie Signaling in JAK/STAT-Dependent Hematopoietic Malignancies in Drosophila melanogaster

A Genetic Screen Reveals an Unexpected Role for Yorkie Signaling in JAK/STAT-Dependent Hematopoietic Malignancies in Drosophila melanogaster

A gain-of-function mutation in the tyrosine kinase JAK2 (JAK2V617F) causes human myeloproliferative neoplasms (MPNs). These patients present with high numbers of myeloid lineage cells and have numerous complications. Since current MPN therapies are not curative, there is a need to find new regulator...

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Bibliographic Details
Main Authors: Abigail M. Anderson, Alessandro A. Bailetti, Elizabeth Rodkin, Atish De, Erika A. Bach
Format: Article
Language:English
Published: Oxford University Press 2017-08-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Drosophila melanogaster
hopscotch
Stat92E
hippo
expanded
yorkie
bantam
warts
Myc
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.044172

Internet

http://g3journal.org/lookup/doi/10.1534/g3.117.044172

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