The pattern of KRAS mutations in metastatic colorectal cancer: a retrospective audit from Sri Lanka

The pattern of KRAS mutations in metastatic colorectal cancer: a retrospective audit from Sri Lanka

Abstract Objective Activating mutations in the KRAS gene, found in approximately 53% of metastatic colorectal cancer (mCRC) cases, can render epidermal growth factor receptor (EGFR) inhibitors ineffective. Regional differences in these mutations have been reported. This is the first study which aims...

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Bibliographic Details
Main Authors: Nirmala Dushyanthi Sirisena, Kemal Deen, Dayupathi Eranda Nipunika Mandawala, Pumindu Herath, Vajira Harshadeva Weerabaddana Dissanayake
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Research Notes
Subjects:
Colorectal carcinoma
Epidermal growth factor receptor
Genotype
KRAS gene
Mutation
Online Access:http://link.springer.com/article/10.1186/s13104-017-2731-5

Internet

http://link.springer.com/article/10.1186/s13104-017-2731-5

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