Hyaluronic acid reduction-sensitive polymeric micelles achieving co-delivery of tumor-targeting paclitaxel/apatinib effectively reverse cancer multidrug resistance

Hyaluronic acid reduction-sensitive polymeric micelles achieving co-delivery of tumor-targeting paclitaxel/apatinib effectively reverse cancer multidrug resistance

Multidrug resistance (MDR) of cancer cells is a significant challenge in chemotherapy, highlighting the urgent medical need for simple and reproducible strategies to reverse this process. Here, we report the development of an active tumor-targeting and redox-responsive nanoplatform (PA-ss-NP) using...

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Bibliographic Details
Main Authors: Xiaoqing Zhang, Xiaomei Ren, Jiayin Tang, Jiangtao Wang, Xiang Zhang, Peng He, Chang Yao, Weihe Bian, Lizhu Sun
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Drug Delivery
Subjects:
apatinib
tumor actively targeted
multidrug resistance
co-delivery
paclitaxel
Online Access:http://dx.doi.org/10.1080/10717544.2020.1770373

Internet

http://dx.doi.org/10.1080/10717544.2020.1770373

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