Liver fibrosis and CD206+ macrophage accumulation are suppressed by anti-GM-CSF therapy
Background & Aims: Chronic liver inflammation leads to fibrosis and cirrhosis and is associated with an accumulation of intrahepatic TNFα-secreting CD206+ macrophages, which may participate in maintaining chronic liver disease in a GM-CSF-dependent manner. We aimed to elucidate the exact role of...
Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-02-01
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Series: | JHEP Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589555919301569 |