Liver fibrosis and CD206+ macrophage accumulation are suppressed by anti-GM-CSF therapy

Liver fibrosis and CD206+ macrophage accumulation are suppressed by anti-GM-CSF therapy

Background & Aims: Chronic liver inflammation leads to fibrosis and cirrhosis and is associated with an accumulation of intrahepatic TNFα-secreting CD206+ macrophages, which may participate in maintaining chronic liver disease in a GM-CSF-dependent manner. We aimed to elucidate the exact role of...

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Bibliographic Details
Main Authors: Alfonso Tan-Garcia, Fritz Lai, Joe Poh Sheng Yeong, Sergio E. Irac, Pei Y. Ng, Rasha Msallam, Jeffrey Chun Tatt Lim, Lu-En Wai, Christine Y.L. Tham, Su P. Choo, Tony Lim, Dan Y. Young, Roberta D'Ambrosio, Elisabetta Degasperi, Riccardo Perbellini, Evan Newell, Nina Le Bert, Florent Ginhoux, Antonio Bertoletti, Qingfeng Chen, Charles-Antoine Dutertre
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:JHEP Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555919301569

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http://www.sciencedirect.com/science/article/pii/S2589555919301569

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