Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice

iRhoms are closely related to rhomboid intramembrane proteases but lack catalytic activity. In mammals iRhoms are known to regulate the trafficking of TACE, the protease that cleaves the membrane bound inflammatory cytokine TNF. We have mapped a spontaneously occurring mouse mutation with a loss of...

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Bibliographic Details
Main Authors: Owen M. Siggs, Adam Grieve, Hongmei Xu, Paul Bambrough, Yonka Christova, Matthew Freeman
Format: Article
Language:English
Published: The Company of Biologists 2014-11-01
Series:Biology Open
Subjects:
Online Access:http://bio.biologists.org/content/3/12/1151