Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells

Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells

Transforming growth factor β-activated kinase 1 (TAK1) is critical for survival of many KRAS mutated colorectal cancer cells, and TAK1 inhibition with 5Z-7-oxozeaenol has been associated with oxidative stress leading to tumor cell killing. When SW 620 and HCT 116 human colon cancer cells were treate...

Full description

Bibliographic Details
Main Authors: Jennifer E. Hrabe, Brianne R. O’Leary, Melissa A. Fath, Samuel N. Rodman, Anna M. Button, Frederick E. Domann, Douglas R. Spitz, James J. Mezhir
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231715000555

Internet

http://www.sciencedirect.com/science/article/pii/S2213231715000555

Similar Items