Synthetic Biology: Emerging Concepts to Design and Advance Adeno‐Associated Viral Vectors for Gene Therapy

Synthetic Biology: Emerging Concepts to Design and Advance Adeno‐Associated Viral Vectors for Gene Therapy

Abstract Three recent approvals and over 100 ongoing clinical trials make adeno‐associated virus (AAV)‐based vectors the leading gene delivery vehicles in gene therapy. Pharmaceutical companies are investing in this small and nonpathogenic gene shuttle to increase the therapeutic portfolios within t...

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Bibliographic Details
Main Authors: Hanna J. Wagner, Wilfried Weber, Martin Fussenegger
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Advanced Science
Subjects:
AAV; adeno‐associated virus
capsid modifications
engineering
gene delivery
molecular switches
vector design
Online Access:https://doi.org/10.1002/advs.202004018

Internet

https://doi.org/10.1002/advs.202004018

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