Regional methylome profiling reveals dynamic epigenetic heterogeneity and convergent hypomethylation of stem cell quiescence-associated genes in breast cancer following neoadjuvant chemotherapy

Regional methylome profiling reveals dynamic epigenetic heterogeneity and convergent hypomethylation of stem cell quiescence-associated genes in breast cancer following neoadjuvant chemotherapy

Abstract Background Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ~ 30% of patients with breast cancer. However, aberrant DNA methylation alterations are frequent events during breast cancer progression and acquisition of chemoresistance. We aimed to characterize t...

Full description

Bibliographic Details
Main Authors: Yumei Luo, Juan Huang, Yi Tang, Xitu Luo, Lingxia Ge, Xiujie Sheng, Xiaofang Sun, Yaoyong Chen, Detu Zhu
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Cell & Bioscience
Subjects:
Breast cancer
Neoadjuvant chemotherapy
Chemoresistance
DNA methylation
Epigenetic heterogeneity
High-density methylation microarray
Online Access:http://link.springer.com/article/10.1186/s13578-019-0278-y

Internet

http://link.springer.com/article/10.1186/s13578-019-0278-y

Similar Items