Regional methylome profiling reveals dynamic epigenetic heterogeneity and convergent hypomethylation of stem cell quiescence-associated genes in breast cancer following neoadjuvant chemotherapy

Regional methylome profiling reveals dynamic epigenetic heterogeneity and convergent hypomethylation of stem cell quiescence-associated genes in breast cancer following neoadjuvant chemotherapy

Abstract Background Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ~ 30% of patients with breast cancer. However, aberrant DNA methylation alterations are frequent events during breast cancer progression and acquisition of chemoresistance. We aimed to characterize t...

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Bibliographic Details
Main Authors: Yumei Luo, Juan Huang, Yi Tang, Xitu Luo, Lingxia Ge, Xiujie Sheng, Xiaofang Sun, Yaoyong Chen, Detu Zhu
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Cell & Bioscience
Subjects:
Breast cancer
Neoadjuvant chemotherapy
Chemoresistance
DNA methylation
Epigenetic heterogeneity
High-density methylation microarray
Online Access:http://link.springer.com/article/10.1186/s13578-019-0278-y

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