Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors

Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors

Abstract Programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) is a negative modulatory signaling pathway for activation of T cell. It is acknowledged that PD-1/PD-L1 axis plays a crucial role in the progression of tumor by altering status of immune surveillance. As one of the...

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Bibliographic Details
Main Authors: Ming Yi, Dechao Jiao, Hanxiao Xu, Qian Liu, Weiheng Zhao, Xinwei Han, Kongming Wu
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Molecular Cancer
Subjects:
PD-1/PD-L1 inhibitors
Predictive biomarkers
Tumor mutational burden
Microsatellite instability
Gut microbiota
Peripheral biomarker
Online Access:http://link.springer.com/article/10.1186/s12943-018-0864-3

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http://link.springer.com/article/10.1186/s12943-018-0864-3

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