Protein Tyrosine Phosphatase Receptor S Acts as a Metastatic Suppressor in Malignant Peripheral Nerve Sheath Tumor via Profilin 1-Induced Epithelial-Mesenchymal Transition

Protein Tyrosine Phosphatase Receptor S Acts as a Metastatic Suppressor in Malignant Peripheral Nerve Sheath Tumor via Profilin 1-Induced Epithelial-Mesenchymal Transition

Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas with over half of cases developed in the context of neurofibromatosis type 1. Surgical resection is the only effective therapy for MPNST. The prognosis is very dismal once recurrence or metastasis occurs. Epithelial-mesenchymal...

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Bibliographic Details
Main Authors: Jie-Yi Ren, Yi-Hui Gu, Xi-Wei Cui, Man-Mei Long, Wei Wang, Cheng-Jiang Wei, Bin Gu, Hai-Bing Zhang, Qing-Feng Li, Zhi-Chao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
PTPRS
MPNST
epithelial-mesenchymal transition
actin-binding proteins
profilin 1
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.582220/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.582220/full

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