E17110 promotes reverse cholesterol transport with liver X receptor β agonist activity in vitro

E17110 promotes reverse cholesterol transport with liver X receptor β agonist activity in vitro

Liver X receptor (LXR) plays an important role in reverse cholesterol transport (RCT), and activation of LXR could reduce atherosclerosis. In the present study we used a cell-based screening method to identify new potential LXRβ agonists. A novel benzofuran-2-carboxylate derivative was identified wi...

Full description

Bibliographic Details
Main Authors: Ni Li, Xiao Wang, Peng Liu, Duo Lu, Wei Jiang, Yanni Xu, Shuyi Si
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
LXRβ
Atherosclerosis
ABCA1
ABCG1
Reverse cholesterol transport
Cholesterol efflux
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383516300053

Internet

http://www.sciencedirect.com/science/article/pii/S2211383516300053

Similar Items