Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway

Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway

Cellular senescence is an important in vivo mechanism that prevents the propagation of damaged cells. However, the precise mechanisms regulating senescence are not well characterized. Here, we find that ITGB3 (integrin beta 3 or β3) is regulated by the Polycomb protein CBX7. β3 expression accelerate...

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Bibliographic Details
Main Authors: Valentina Rapisarda, Michela Borghesan, Veronica Miguela, Vesela Encheva, Ambrosius P. Snijders, Amaia Lujambio, Ana O’Loghlen
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
senescence
integrin
aging
CBX7
ITGB3
β3
SASP
TGFβ
cilengitide
Palbociclib
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717301778

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http://www.sciencedirect.com/science/article/pii/S2211124717301778

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