Computational analysis of the amino acid interactions that promote or decrease protein solubility

Abstract The solubility of globular proteins is a basic biophysical property that is usually a prerequisite for their functioning. In this study, we probed the solubility of globular proteins with the help of the statistical potential formalism, in view of objectifying the connection of solubility w...

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Bibliographic Details
Main Authors: Qingzhen Hou, Raphaël Bourgeas, Fabrizio Pucci, Marianne Rooman
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-018-32988-w