Disturbances of ligand potency and enhanced degradation of the human glycine receptor at affected positions G160 and T162 originally identified in patients suffering from hyperekplexia

Disturbances of ligand potency and enhanced degradation of the human glycine receptor at affected positions G160 and T162 originally identified in patients suffering from hyperekplexia

Ligand-binding of Cys-loop receptors is determined by N-terminal extracellular loop structures from the plus as well as from the minus side of two adjacent subunits in the pentameric receptor complex. An aromatic residue in loop B of the glycine receptor (GlyR) undergoes direct interaction with the...

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Bibliographic Details
Main Authors: Sinem eAtak, Georg eLanglhofer, Natascha eSchaefer, Denise eKessler, Heike eMeiselbach, Carolyn eDelto, Hermann eSchindelin, Carmen eVillmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Cys-loop receptor
glycine receptor
hyperekplexia
loop B
side chain properties
ligand-potencies
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00079/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00079/full

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