Integrated proteotranscriptomics of breast cancer reveals globally increased protein-mRNA concordance associated with subtypes and survival

Integrated proteotranscriptomics of breast cancer reveals globally increased protein-mRNA concordance associated with subtypes and survival

Abstract Background Transcriptome analysis of breast cancer discovered distinct disease subtypes of clinical significance. However, it remains a challenge to define disease biology solely based on gene expression because tumor biology is often the result of protein function. Here, we measured global...

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Bibliographic Details
Main Authors: Wei Tang, Ming Zhou, Tiffany H. Dorsey, DaRue A. Prieto, Xin W. Wang, Eytan Ruppin, Timothy D. Veenstra, Stefan Ambs
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Genome Medicine
Subjects:
Breast cancer
Proteomics
Gene expression profiling
Systems analysis
Transcription
Survival
Online Access:http://link.springer.com/article/10.1186/s13073-018-0602-x

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http://link.springer.com/article/10.1186/s13073-018-0602-x

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