Time-dependent selected reaction monitoring-based GC-MS/MS method for estimation of genotoxic impurities in new antibacterial agent: alalevonadifloxacin mesylate

Time-dependent selected reaction monitoring-based GC-MS/MS method for estimation of genotoxic impurities in new antibacterial agent: alalevonadifloxacin mesylate

Abstract Alalevonadifloxacin mesylate (ALA), pro-drug of levonadifloxacin is a new antibiotic approved in India to treat infections caused by Gram-positive bacteria. Alkyl mesylates (AMs) are known genotoxic impurities (GTI’s) formed in drug substances isolated as mesylate salts. Time-dependent sele...

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Bibliographic Details
Main Authors: Vinod K. Ahirrao, Rajiv A. Jadhav, Vipul P. Rane, Harshal R. Bhamare, Ravindra D. Yeole
Format: Article
Language:English
Published: SpringerOpen 2020-06-01
Series:Journal of Analytical Science and Technology
Subjects:
Alalevonadifloxacin
GC-MS/MS
Time-dependent SRM
Alkyl mesylates
Online Access:http://link.springer.com/article/10.1186/s40543-020-00214-w

Internet

http://link.springer.com/article/10.1186/s40543-020-00214-w

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