Patterns of Co-occurring Gray Matter Concentration Loss Across the Huntington Disease Prodrome

Patterns of Co-occurring Gray Matter Concentration Loss Across the Huntington Disease Prodrome

Huntington disease is caused by an abnormally expanded CAG trinucleotide repeat in the HTT gene. Age and CAG-expansion number are related to age at diagnosis, and can be used to index disease progression. However, observed onset-age variability suggests that other factors also modulate progression....

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Bibliographic Details
Main Authors: Jennifer Ashley Ciarochi, Vince D Calhoun, Spencer Lourens, Jeffrey D Long, Hans J Johnson, Jeremy Bockholt, Jingyu Liu, Sergey M Plis, Jane Paulsen, Jessica A Turner
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Neurology
Subjects:
Cross-Sectional Studies
Humans
Magnetic Resonance Imaging
Movement Disorders
disease progression
Prodromal Symptoms
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00147/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00147/full

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