Diterpenylhydroquinones from Natural ent-Labdanes Induce Apoptosis through Decreased Mitochondrial Membrane Potential

Diterpenylhydroquinones from Natural ent-Labdanes Induce Apoptosis through Decreased Mitochondrial Membrane Potential

In this study, we examined the cytotoxic effects of seven ent-labdane derivatives 1–7 (0–100 μM) in different human cancer cell lines. Our results showed that compounds 1–3 exhibited significant dose-dependent inhibition on the growth of the three different human cell lines, according to the sulphor...

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Bibliographic Details
Main Authors: Mauricio Cuellar, Enrique Werner, Iván Montenegro, Alejandro Madrid, Joan Villena, Luis Espinoza
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:Molecules
Subjects:
diterpenylhydroquinones
ent-labdanes
cancer cells
apoptosis, caspase 3 activity
mitochondrial membrane potential
Calceolaria inamoena
Online Access:http://www.mdpi.com/1420-3049/18/5/5348

Internet

http://www.mdpi.com/1420-3049/18/5/5348

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