The Impact of Chronic Mild Stress and Agomelatine Treatment on the Expression Level and Methylation Status of Genes Involved in Tryptophan Catabolic Pathway in PBMCs and Brain Structures

The Impact of Chronic Mild Stress and Agomelatine Treatment on the Expression Level and Methylation Status of Genes Involved in Tryptophan Catabolic Pathway in PBMCs and Brain Structures

Depression is the serious mental disorder. Previous studies suggest that the development mechanism of depression may be associated with disorders of the tryptophan catabolic pathway (TRYCAT). Thus, this study investigates the effect of agomelatine treatment on the expression and methylation status o...

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Bibliographic Details
Main Authors: Paulina Wigner, Ewelina Synowiec, Paweł Jóźwiak, Piotr Czarny, Katarzyna Białek, Michal Bijak, Janusz Szemraj, Piotr Gruca, Mariusz Papp, Tomasz Sliwinski
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Genes
Subjects:
chronic mild stress
depression
agomelatine
tryptophan catabolic pathway
gene expression and methylation
Online Access:https://www.mdpi.com/2073-4425/11/9/1093

Internet

https://www.mdpi.com/2073-4425/11/9/1093

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