ANGPTL4 Induces TMZ Resistance of Glioblastoma by Promoting Cancer Stemness Enrichment via the EGFR/AKT/4E-BP1 Cascade

ANGPTL4 Induces TMZ Resistance of Glioblastoma by Promoting Cancer Stemness Enrichment via the EGFR/AKT/4E-BP1 Cascade

Glioblastoma (GBM) is the most aggressive type of brain tumor, with strong invasiveness and a high tolerance to chemotherapy. Despite the current standard treatment combining temozolomide (TMZ) and radiotherapy, glioblastoma can be incurable due to drug resistance. The existence of glioma stem-like...

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Bibliographic Details
Main Authors: Yu-Ting Tsai, An-Chih Wu, Wen-Bin Yang, Tzu-Jen Kao, Jian-Ying Chuang, Wen-Chang Chang, Tsung-I. Hsu
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:International Journal of Molecular Sciences
Subjects:
glioblastoma
angiopoietin-like 4
glioma stem-like cells
Online Access:https://www.mdpi.com/1422-0067/20/22/5625

Internet

https://www.mdpi.com/1422-0067/20/22/5625

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