Differential effects of two MRI contrast agents on the integrity and distribution of rAAV2 and rAAV5 in the rat striatum

Differential effects of two MRI contrast agents on the integrity and distribution of rAAV2 and rAAV5 in the rat striatum

Intraoperative magnetic resonance imaging (MRI) has been proposed as a method to optimize intracerebral targeting and for tracking infusate distribution in gene therapy trials for nervous system disorders. We thus investigated possible effects of two MRI contrast agents, gadoteridol (Gd) and galbumi...

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Bibliographic Details
Main Authors: Sue Osting, Antonette Bennett, Shelby Power, Jordan Wackett, Samuel A Hurley, Andrew L Alexander, Mavis Agbandje-Mckena, Corinna Burger
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050116300699

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http://www.sciencedirect.com/science/article/pii/S2329050116300699

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