Humanized GPRC6A KGKY is a gain-of-function polymorphism in mice
Abstract GPRC6A is proposed to regulate energy metabolism in mice, but in humans a KGKY polymorphism in the third intracellular loop (ICL3) is proposed to result in intracellular retention and loss-of-function. To test physiological importance of this human polymorphism in vivo, we performed targete...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-07-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-68113-z |