Caveolin-1 regulation of Sp1 controls production of the antifibrotic protein follistatin in kidney mesangial cells

Caveolin-1 regulation of Sp1 controls production of the antifibrotic protein follistatin in kidney mesangial cells

Abstract Background We previously showed that caveolin-1 (cav-1), an integral membrane protein, is required for the synthesis of matrix proteins by glomerular mesangial cells (MC). In a previous study to understand how cav-1 is involved in regulating matrix production, we had identified significant...

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Bibliographic Details
Main Authors: Neel Mehta, Dan Zhang, Renzhong Li, Tony Wang, Agata Gava, Pavithra Parthasarathy, Bo Gao, Joan C. Krepinsky
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Cell Communication and Signaling
Subjects:
Caveolin-1
Mesangial cells
Follistatin
Sp1
Renal fibrosis
Online Access:http://link.springer.com/article/10.1186/s12964-019-0351-5

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http://link.springer.com/article/10.1186/s12964-019-0351-5

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