Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells

Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells

<p>Abstract</p> <p>Background</p> <p>Microglia, the resident macrophage-like cells in the brain, regulate innate immune responses in the CNS to protect neurons. However, excessive activation of microglia contributes to neurodegenerative diseases. Corticosteroids are pot...

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Bibliographic Details
Main Authors: Chantong Boonrat, Kratschmar Denise V, Nashev Lyubomir G, Balazs Zoltan, Odermatt Alex
Format: Article
Language:English
Published: BMC 2012-11-01
Series:Journal of Neuroinflammation
Subjects:
Mineralocorticoid receptor
Glucocorticoid receptor
11β-hydroxysteroid dehydrogenase
Inflammation
Interleukin-6
NF-κB
Online Access:http://www.jneuroinflammation.com/content/9/1/260

Internet

http://www.jneuroinflammation.com/content/9/1/260

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