Stromal Metalloproteinase-9 Is Essential to Angiogenesis and Progressive Growth of Orthotopic Human Pancreatic Cancer in Parabiont Nude Mice

Stromal Metalloproteinase-9 Is Essential to Angiogenesis and Progressive Growth of Orthotopic Human Pancreatic Cancer in Parabiont Nude Mice

We determined whether host matrix metalloproteinase (MMP) 9 is essential to angiogenesis and to the growth of L3.6pl human pancreatic cancer cells implanted into the pancreas of wild-type (MMP−9+/+) and knockout (MMP−9−/−) nude mice. Four weeks after tumor cell injection, pancreatic tumors in MMP−9...

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Bibliographic Details
Main Authors: Toru Nakamura, Toshio Kuwai, Jang-Seong Kim, Dominic Fan, Sun-Jin Kim, Isaiah J. Fidler
Format: Article
Language:English
Published: Elsevier 2007-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
MMP−9
parabiosis
pancreatic cancer
angiogenesis
orthotopic model
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800261

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http://www.sciencedirect.com/science/article/pii/S1476558607800261

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