Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents

Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents

The complex nature of Alzheimer’s disease calls for multidirectional treatment. Consequently, the search for multi-target-directed ligands may lead to potential drug candidates. The aim of the present study is to seek multifunctional compounds with expected activity against disease-modifying and sym...

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Bibliographic Details
Main Authors: Dawid Panek, Anna Więckowska, Anna Pasieka, Justyna Godyń, Jakub Jończyk, Marek Bajda, Damijan Knez, Stanislav Gobec, Barbara Malawska
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Molecules
Subjects:
isoindoline-1,3-dione derivatives
cholinesterase inhibitors
BACE-1 inhibitors
Aβ-aggregation
molecular modeling
multiple anti-Alzheimer’s ligands
Online Access:http://www.mdpi.com/1420-3049/23/2/347

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http://www.mdpi.com/1420-3049/23/2/347

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