Neuronal scaffolding protein spinophilin is integral for cocaine-induced behavioral sensitization and ERK1/2 activation

Neuronal scaffolding protein spinophilin is integral for cocaine-induced behavioral sensitization and ERK1/2 activation

Abstract Spinophilin is a scaffolding protein enriched in dendritic spines with integral roles in the regulation of spine density and morphology, and the modulation of synaptic plasticity. The ability of spinophilin to alter synaptic strength appears to involve its scaffolding of key synaptic protei...

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Bibliographic Details
Main Authors: Lorena Bianchine Areal, Alison Hamilton, Cristina Martins-Silva, Rita Gomes Wanderley Pires, Stephen S. G. Ferguson
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Molecular Brain
Subjects:
Drug addiction
Spinophilin
Cocaine
Behavioral sensitization
Online Access:http://link.springer.com/article/10.1186/s13041-019-0434-7

Internet

http://link.springer.com/article/10.1186/s13041-019-0434-7

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