High Intra- and Inter-Tumoral Heterogeneity of RAS Mutations in Colorectal Cancer

High Intra- and Inter-Tumoral Heterogeneity of RAS Mutations in Colorectal Cancer

Approximately 30% of patients with wild type RAS metastatic colorectal cancer are non-responders to anti-epidermal growth factor receptor monoclonal antibodies (anti-EGFR mAbs), possibly due to undetected tumoral subclones harboring RAS mutations. The aim of this study was to analyze the distributio...

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Bibliographic Details
Main Authors: Marion Jeantet, David Tougeron, Gaelle Tachon, Ulrich Cortes, Céline Archambaut, Gaelle Fromont, Lucie Karayan-Tapon
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:International Journal of Molecular Sciences
Subjects:
colorectal cancer
RAS mutation
intra-tumoral heterogeneity
inter-tumoral heterogeneity
Online Access:http://www.mdpi.com/1422-0067/17/12/2015

Internet

http://www.mdpi.com/1422-0067/17/12/2015

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